The functional consequences of age-related changes in microRNA expression in skeletal muscle.

ABSTRACT: A common characteristic of ageing is disrupted homeostasis between growth and atrophy of skeletal muscle resulting in loss of muscle mass and function, which is associated with sarcopenia. Sarcopenia is related to impaired balance, increased falls and decline in quality of life of older people. Ageing-related transcriptome and proteome changes in skeletal muscle have been characterised, however the molecular mechanisms underlying sarcopenia are still not fully understood. microRNAs are novel regulators of gene expression known to modulate skeletal muscle development and homeostasis. Expression of numerous microRNAs is disrupted in skeletal muscle with age however, the functional consequences of this are not yet understood. Given that a single microRNA can simultaneously affect multiple sig

SUBMITTER: Soriano-Arroquia A 

PROVIDER: S-EPMC4889642 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature