APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.

ABSTRACT:

Objective

To examine the association between consumption of seafood and long-chain n-3 fatty acids with change in 5 cognitive domains over an average of 4.9 years.

Methods

From an ongoing longitudinal, community-based epidemiologic study of aging and dementia (the Rush Memory and Aging Project), we included 915 participants (age 81.4 ± 7.2 years, 25% men) who had completed at least one follow-up cognitive assessment and dietary data. Diet was assessed by semiquantitative food frequency questionnaire. Scores for global cognitive function and 5 cognitive domains (episodic, semantic, and working memory, perceptual speed, and visuospatial ability) were assessed using 19 cognitive tests. Mixed models adjusted for multiple risk factors of cognitive change were used to assess the a

SUBMITTER: van de Rest O 

PROVIDER: S-EPMC4891213 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature