Dataset Information

APOE ?4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.

ABSTRACT:

Objective

To examine the association between consumption of seafood and long-chain n-3 fatty acids with change in 5 cognitive domains over an average of 4.9 years.

Methods

From an ongoing longitudinal, community-based epidemiologic study of aging and dementia (the Rush Memory and Aging Project), we included 915 participants (age 81.4 ± 7.2 years, 25% men) who had completed at least one follow-up cognitive assessment and dietary data. Diet was assessed by semiquantitative food frequency questionnaire. Scores for global cognitive function and 5 cognitive domains (episodic, semantic, and working memory, perceptual speed, and visuospatial ability) were assessed using 19 cognitive tests. Mixed models adjusted for multiple risk factors of cognitive change were used to assess the associations.

Results

Consumption of seafood was associated with slower decline in semantic memory (? = 0.024; p = 0.03) and perceptual speed (? = 0.020; p = 0.05) in separate models adjusted for age, sex, education, participation in cognitive activities, physical activity, alcohol consumption, smoking, and total energy intake. In secondary analyses, APOE ?4 carriers demonstrated slower rates of decline in global cognition and in multiple cognitive domains with weekly seafood consumption and with moderate to high long-chain n-3 fatty acid intake from food. These associations were not present in APOE ?4 noncarriers. Higher intake levels of ?-linolenic acid were associated with slower global cognitive decline, but also only in APOE ?4 carriers.

Conclusions

These results suggest protective relations of one meal per week of seafood and long-chain n-3 fatty acids against decline in multiple cognitive domains. The role of APOE ?4 in this association needs further study.

SUBMITTER: van de Rest O

PROVIDER: S-EPMC4891213 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.

van de Rest Ondine O Wang Yamin Y Barnes Lisa L LL Tangney Christine C Bennett David A DA Morris Martha Clare MC

Neurology 20160504 22

<h4>Objective</h4>To examine the association between consumption of seafood and long-chain n-3 fatty acids with change in 5 cognitive domains over an average of 4.9 years.<h4>Methods</h4>From an ongoing longitudinal, community-based epidemiologic study of aging and dementia (the Rush Memory and Aging Project), we included 915 participants (age 81.4 ± 7.2 years, 25% men) who had completed at least one follow-up cognitive assessment and dietary data. Diet was assessed by semiquantitative food freq ...[more]

PMID: 27164694

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