No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.

ABSTRACT:

Background

Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.

Methods

We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.

Results

No significant association was found between the SCZ patients and controls for any allele or geno

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4932686 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature