Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.

ABSTRACT:

Background

The relationships of thrombin generation (TG) with cardiovascular disease risk are underevaluated in population-based cohorts.

Objectives

To evaluate the relationships of TG influenced by the contact and tissue factor coagulation pathways ex vivo with common single-nucleotide polymorphisms (SNPs) and incident cardiovascular disease and stroke.

Patients/methods

We measured peak TG (pTG) in baseline plasma samples of Cardiovascular Health Study participants (n = 5411), both with and without inhibitory anti-factor XIa antibody (pTG/FXIa(-) ). We evaluated their associations with ~ 50 000 SNPs by using the IBCv2 genotyping array, and with incident cardiovascular disease and stroke events over a median follow-up of 13.2 years.

Results

The minor allele for

SUBMITTER: Olson NC 

PROVIDER: S-EPMC4946166 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature