Ontology highlight
ABSTRACT:
SUBMITTER: Hagemeyer N
PROVIDER: S-EPMC5010043 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20160713 16
Recent studies have shown that tissue macrophages (MΦ) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have proposed that developmentally distinct tissue MΦ can be identified based on the differential expression of F4/80 and CD11b, but whether a characteristic transcriptional profile exists is largely unknown. Here, we took advantage of an inducible fate-mapping system that facilitated the identification of CD45(+)c-kit(-)C ...[more]