Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc^+/1638N Mice: Comparisons and Contrasts.

ABSTRACT: Obesity is an established risk factor for colorectal cancer (CRC). Our previous study indicated that obesity increases activity of the pro-tumorigenic Wnt-signaling. Presently, we sought to further advance our understanding of the mechanisms by which obesity promotes CRC by examining associations between microbiome, inflammation and Wnt-signaling in Apc^+/1638N mice whose obesity was induced by one of two modalities, diet- or genetically-induced obesity. Three groups were employed: Apc^+/1638NLepr^+/+ fed a low fat diet (10% fat), Apc^+/1638NLepr^+/+ fed a high fat diet (60% fat, diet-induced obesity), and Apc^+/1638NLepr^db/db fed a low fat diet (genetically-induced obesity). All animals received diets for

SUBMITTER: Liu W 

PROVIDER: S-EPMC5039360 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature