The prevalence of drug resistance among treatment-naive HIV-1-infected individuals in China during pre- and post- 2004.

ABSTRACT:

Background

The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic.

Methods

We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database.

Results

Of 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend i

SUBMITTER: Li H 

PROVIDER: S-EPMC5080753 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature