PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.

ABSTRACT: Current treatment methods for patients diagnosed with gliomas have shown limited success. This is partly due to the lack of prognostic genes available to accurately predict disease outcomes. The aim of this study was to investigate novel prognostic genes based on the molecular profile of tumor samples and their correlation with clinical parameters. In the current study, microarray data (GSE4412 and GSE7696) downloaded from Gene Expression Omnibus were used to identify differentially expressed prognostic genes (DEPGs) by significant analysis of microarray (SAM) between long-term survivors (>2 years) and short-term survivors (≤2 years). DEPGs generated from these two datasets were intersected to obtain a list of common DEPGs. The expression of a subset of common DEPGs was then independently

SUBMITTER: Gao YF 

PROVIDER: S-EPMC5133809 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature