Ontology highlight
ABSTRACT: Objective
Both bipolar spectrum disorders (BPSD) and attention deficit hyperactivity disorder (ADHD) present with emotion-regulation deficits, but require different clinical management. We examined how the neurobiological underpinnings of emotion regulation might differentiate youth with BPSD versus ADHD (and healthy controls, HCs), specifically assessing functional connectivity (FxC) of amygdala-prefrontal circuitry during an implicit emotion processing task.Methods
We scanned a subset of the Longitudinal Assessment of Manic Symptoms (LAMS) sample, a clinically recruited cohort with elevated behavioral and emotional dysregulation, and age/sex-ratio matched HCs. Our sample consisted of 22 youth with BPSD, 30 youth with ADHD/no BPSD, and 26 HCs. We used generalized psychophysiological interaction (gPPI) to calculate group differences to emerging emotional faces vs. morphing shapes in FxC between bilateral amygdala and ventral prefrontal cortex/anterior cingulate cortex.Results
FxC between amygdala and left ventrolateral prefrontal cortex (VLPFC) in response to emotions vs. shapes differed by group (p=.05): while BPSD showed positive FxC (emotions>shapes), HC and ADHD showed inverse FxC (emotionsConclusions
Youth with BPSD showed abnormally positive FxC between amygdala and regions in the ventral prefrontal cortex during emotion processing. In particular, the amygdala-VLPFC finding was specific to BPSD, and not influenced by other diagnoses or medications.
SUBMITTER: Hafeman D
PROVIDER: S-EPMC5154789 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Hafeman Danella D Bebko Genna G Bertocci Michele A MA Fournier Jay C JC Chase Henry W HW Bonar Lisa L Perlman Susan B SB Travis Michael M Gill Mary Kay MK Diwadkar Vaibhav A VA Sunshine Jeffrey L JL Holland Scott K SK Kowatch Robert A RA Birmaher Boris B Axelson David D Horwitz Sarah M SM Arnold L Eugene LE Fristad Mary A MA Frazier Thomas W TW Youngstrom Eric A EA Findling Robert L RL Phillips Mary L ML
Journal of affective disorders 20161011
<h4>Objective</h4>Both bipolar spectrum disorders (BPSD) and attention deficit hyperactivity disorder (ADHD) present with emotion-regulation deficits, but require different clinical management. We examined how the neurobiological underpinnings of emotion regulation might differentiate youth with BPSD versus ADHD (and healthy controls, HCs), specifically assessing functional connectivity (FxC) of amygdala-prefrontal circuitry during an implicit emotion processing task.<h4>Methods</h4>We scanned a ...[more]