Dataset Information

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.

ABSTRACT:

Objective

The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS.

Methods

Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases. Sex-stratified associations between MS risk and age at symptom onset with both BMI and pubertal factors were estimated controlling for race and ethnicity.

Results

Only 11% of girls and 15% of boys were prepubertal (Tanner stage I) at MS onset. 80% of girls had onset of MS after menarche. BMI percentiles were higher in MS cases versus controls (girls: P < 0.001; boys: P = 0.018). BMI was associated with odds of MS in multivariate models in postpubertal girls (OR = 1.60, 95% confidence interval [CI]: 1.12, 2.27, P = 0.009) and boys (OR = 1.43, 95% CI: 1.08, 1.88, P = 0.011). In girls with MS onset after menarche, higher BMI was associated with younger age at first symptoms (P = 0.031). Younger menarche was associated with stronger effects of BMI through mediation and interaction analysis. In pubertal/postpubertal boys, 89% of whom were obese/overweight, earlier sexual maturity was associated with earlier onset of MS (P < 0.001).

Interpretation

Higher BMI in early adolescence is a risk factor for MS in girls and boys. Earlier age at sexual maturity contributes to earlier age at MS onset, particularly in association with obesity.

SUBMITTER: Chitnis T

PROVIDER: S-EPMC5224818 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.

Chitnis Tanuja T Graves Jennifer J Weinstock-Guttman Bianca B Belman Anita A Olsen Cody C Misra Madhusmita M Aaen Gregory G Benson Leslie L Candee Meghan M Gorman Mark M Greenberg Benjamin B Krupp Lauren L Lotze Timothy T Mar Soe S Ness Jayne J Rose John J Rubin Jennifer J Schreiner Teri T Tillema Jan J Waldman Amy A Rodriguez Moses M Casper Charlie C Waubant Emmanuelle E

Annals of clinical and translational neurology 20161104 12

<h4>Objective</h4>The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS.<h4>Methods</h4>Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset f ...[more]

PMID: 28097202

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Dataset Information

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.

Objective

Methods

Results

Interpretation

Publications

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.

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