Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against β₁-Adrenergic Receptors.

ABSTRACT:

Background

Among various cardiac autoantibodies (AAbs), those recognizing the β₁-adrenergic receptor (β₁AR) demonstrate agonist-like effects and induce myocardial damage that can be reversed by β-blockers and immunoglobulin G3 (IgG3) immunoadsorption.

Objectives

The goal of this study was to investigate the role of β₁AR-AAbs belonging to the IgG3 subclass in patients with recent-onset cardiomyopathy.

Methods

Peripheral blood samples were drawn at enrollment in patients with recent-onset cardiomyopathy (left ventricular ejection fraction [LVEF] ≤0.40; <6 months). The presence of IgG and IgG3-β₁AR-AAb was determined, and echocardiograms were assessed, at baseline and 6 months. Patients were followed up for ≤48 months.

Resul

SUBMITTER: Nagatomo Y 

PROVIDER: S-EPMC5330212 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature