Suppressive IL-17A⁺Foxp3⁺ and ex-Th17 IL-17A^negFoxp3⁺ T_reg cells are a source of tumour-associated T_reg cells.

ABSTRACT: Th17 and regulatory T (T_reg) cells are integral in maintaining immune homeostasis and Th17-T_reg imbalance is associated with inflammatory immunosuppression in cancer. Here we show that Th17 cells are a source of tumour-induced Foxp3⁺ cells. In addition to natural (n)T_reg and induced (i)T_reg cells that develop from naive precursors, suppressive IL-17A⁺Foxp3⁺ and ex-Th17 Foxp3⁺ cells are converted from IL-17A⁺Foxp3^neg cells in tumour-bearing mice. Metabolic phenotyping of Foxp3-expressing IL-17A⁺, ex-Th17 and iT_reg cells demonstrates the dissociation between the metabolic fitness and the suppressive function of Foxp3-expressing T_reg cell subsets. Alth

SUBMITTER: Downs-Canner S 

PROVIDER: S-EPMC5355894 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature