Proteome dynamics during postnatal mouse corpus callosum development.

ABSTRACT: Formation of cortical connections requires the precise coordination of numerous discrete phases. This is particularly significant with regard to the corpus callosum, whose development undergoes several dynamic stages including the crossing of axon projections, elimination of exuberant projections, and myelination of established tracts. To comprehensively characterize the molecular events in this dynamic process, we set to determine the distinct temporal expression of proteins regulating the formation of the corpus callosum and their respective developmental functions. Mass spectrometry-based proteomic profiling was performed on early postnatal mouse corpus callosi, for which limited evidence has been obtained previously, using stable isotope of labeled amino acids in mammals (SILAM). The a

SUBMITTER: Son AI 

PROVIDER: S-EPMC5368975 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature