Choroidal thinning: Alzheimer's disease and aging.

ABSTRACT:

Introduction

The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients.

Methods

CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data.

Results

Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001-comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea.

Di

SUBMITTER: Cunha JP 

PROVIDER: S-EPMC5390660 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature