Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries.

ABSTRACT:

Background

The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected.

Methods

We identified 545 women with double independent primary cancers of the breast and ovary reported to the California Cancer Registry from 1999 to 2013 and examined the coincidence of subtype combinations.

Results

For most subtype combinations the observed frequencies were similar to their expected frequencies, but in 103 observed cases vs 43.8 expected (O/E=2.35; 95% CI 1.90-2.81) a triple-negative breast tumour (typically basal-like) was matched with a serous ovarian tumour (typicall

SUBMITTER: Begg CB 

PROVIDER: S-EPMC5396122 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature