Expression of PGC1? in glioblastoma multiforme patients.

ABSTRACT: Peroxisome proliferator-activated receptor ? coactivator 1? (PGC1?) is a key modulator of mitochondrial biogenesis. It is a coactivator of multiple transcription factors and regulates metabolic processes. However, little is known about the expression and function of PGC1? in glioblastoma multiforme (GBM), the most prevalent and invasive type of brain tumor. The purpose of the present study was to investigate the biological function, localization and expression of PGC1? in GBM. It was observed that PGC1? expression is increased in the tumor cells, and a higher level of expression was observed in the mitochondria. Bioinformatics analyses identified that metabolic and mitochondrial genes were highly expressed in GBM cells, with a high PGC1? mRNA expression. Notably, mitochondrial function-associated genes were highly expressed in cells alongside high PGC1? expression. Collectively, the results of the present study indicate that PGC1? is associated with mitochondrial dysfunction in GBM and may have a role in tumor pathogenesis and progression.

SUBMITTER: Cho SY 

PROVIDER: S-EPMC5453058 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature