HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.
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ABSTRACT:
SUBMITTER: Hilimire TA
PROVIDER: S-EPMC5477779 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.
Hilimire Thomas A TA Chamberlain Jeffrey M JM Anokhina Viktoriya V Bennett Ryan P RP Swart Oliver O Myers Jason R JR Ashton John M JM Stewart Ryan A RA Featherston Aaron L AL Gates Kathleen K Helms Eric D ED Smith Harold C HC Dewhurst Stephen S Miller Benjamin L BL
ACS chemical biology 20170505 6
The HIV-1 frameshift-stimulating (FSS) RNA, a regulatory RNA of critical importance in the virus' life cycle, has been posited as a novel target for anti-HIV drug development. We report the synthesis and evaluation of triazole-containing compounds able to bind the FSS with high affinity and selectivity. Readily accessible synthetically, these compounds are less toxic than previously reported olefin congeners. We show for the first time that FSS-targeting compounds have antiviral activity against ...[more]
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