Parental obesity leads to metabolic changes in the F2 generation in Drosophila.

ABSTRACT:

Objective

A significant portion of the heritable risk for complex metabolic disorders cannot be attributed to classic Mendelian genetic factors. At least some of this missing heritability is thought to be due to the epigenetic influence of parental and grandparental metabolic state on offspring health. Previous work suggests that this transgenerational phenomenon is evolutionarily conserved in Drosophila. These studies, however, have all depended on dietary paradigms to alter parental metabolic state, which can have inconsistent heritable effects on the metabolism of offspring.

Methods

Here we use AKHR null alleles to induce obesity in the parental generation and then score both metabolic parameters and genome-wide transcriptional responses in AKHR heter

SUBMITTER: Palu RAS 

PROVIDER: S-EPMC5485226 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature