Body Mass Index and Risk of Alzheimer's Disease: A Mendelian Randomization Study of 399,536 Individuals.

ABSTRACT:

Context

Recently, data on 2,000,000 people established that low body mass index (BMI) is associated with increased risk of dementia. Whether this observational association reflects a causal effect remains to be clarified.

Objective

We tested the hypothesis that there is a causal association between low BMI and high risk of Alzheimer's disease.

Design, setting, and participants

Using a Mendelian randomization approach, we studied 95,578 individuals from the Copenhagen General Population Study (CGPS) with up to 36 years of follow-up and consortia data on 303,958 individuals from the Genetic Investigation of Anthropometric Traits (GIANT) and the International Genomics of Alzheimer's Project (IGAP).

Main outcome measure

Risk of Alzheimer's disease.

Results

T

SUBMITTER: Nordestgaard LT 

PROVIDER: S-EPMC5505195 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature