Transdiagnostic neural markers of emotion-cognition interaction in psychotic disorders.

ABSTRACT: Deficits in working memory (WM) and emotion processing are prominent impairments in psychotic disorders, and have been linked to reduced quality of life and real-world functioning. Translation of knowledge regarding the neural circuitry implementing these deficits into improved diagnosis and targeted treatments has been slow, possibly because of categorical definitions of disorders. Using the dimensional Research Domain Criteria (RDoC) framework, we investigated the clinical and practical utility of transdiagnostic behavioral and neural measures of emotion-related WM disruption across psychotic disorders. Behavioral and functional MRI data were recorded while 53 participants with psychotic disorders and 29 participants with no history of psychosis performed a modified n-back task with fear

SUBMITTER: Sabharwal A 

PROVIDER: S-EPMC5576592 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature