NFATc1 controls the cytotoxicity of CD8⁺ T cells.

ABSTRACT: Cytotoxic T lymphocytes are effector CD8⁺ T cells that eradicate infected and malignant cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse cytotoxic T lymphocytes. Activation of Nfatc1 ^-/- cytotoxic T lymphocytes showed a defective cytoskeleton organization and recruitment of cytosolic organelles to immunological synapses. These cells have reduced cytotoxicity against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria infection. Transcriptome analysis shows diminished RNA levels of numerous genes in Nfatc1 ^-/- CD8⁺ T cells, including Tbx21, Gzmb and genes encoding cytokines and chemokines, and genes controlling glycolysis. Nfatc1 ^-/- , but not Nfatc2 ^-

SUBMITTER: Klein-Hessling S 

PROVIDER: S-EPMC5593830 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature