Ontology highlight
ABSTRACT:
SUBMITTER: Vaz M
PROVIDER: S-EPMC5596892 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cancer cell 20170901 3
We define how chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene. The smoke-induced chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DNA methylation by 10 months. At this time, cells exhibit epithelial-to-mesenchymal changes, anchorage-independent growth, and upregulated RAS/MAPK signaling with silencing of hypermethylated genes, which normal ...[more]