Dataset Information

Relationship between anti-depressant use and lung cancer survival.

ABSTRACT:

Objectives

In recent years, the anti-cancer properties of several commonly used drugs have been explored, with drugs such as aspirin and beta-blockers associated with improved cancer outcomes. Previous preclinical work demonstrated that tricyclic anti-depressants have antitumor efficacy in lung cancer. Our goal was to examine the association between anti-depressant use and survival in lung cancer.

Materials and methods

We examined the association between use of common anti-depressants and survival in 1,097 lung cancer patients from the NCI-Maryland lung cancer study. The types of anti-depressants included in the study were norepinephrine and dopamine reuptake inhibitors, serotonin reuptake inhibitors, selective serotonin reuptake inhibitors, non-selective serotonin reuptake inhibitors, and tricyclic anti-depressants. Anti-depressant use was extracted from the medical history section of a detailed interviewer-administered questionnaire. Specific use in the three months before a lung cancer diagnosis was determined. Cox portioned hazards modeling was used to estimate the association between anti-depressant use with lung cancer-specific death with adjustment for potential confounding co-factors.

Results

Anti-depressant use was associated with extended lung cancer-specific survival. In an analysis of specific classes of anti-depressant use, NDRIs and TCAs were associated with improved survival. Importantly, the extended survival associated with anti-depressants was maintained after adjustment for the clinical indications for these drugs, suggestive of a direct effect on lung cancer biology.

Conclusions

Considering the manageable and largely tolerable side effects of anti-depressants, and the low cost of these drugs, these results indicate that evaluation of anti-depressants as adjunct therapeutics with chemotherapy may have a translational effect for lung cancer patients.

SUBMITTER: Zingone A

PROVIDER: S-EPMC5603309 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Relationship between anti-depressant use and lung cancer survival.

Zingone Adriana A Brown Derek D Bowman Elise D ED Vidal Oscar O Sage Julien J Neal Joel J Ryan Bríd M BM

Cancer treatment and research communications 20170129

<h4>Objectives</h4>In recent years, the anti-cancer properties of several commonly used drugs have been explored, with drugs such as aspirin and beta-blockers associated with improved cancer outcomes. Previous preclinical work demonstrated that tricyclic anti-depressants have antitumor efficacy in lung cancer. Our goal was to examine the association between anti-depressant use and survival in lung cancer.<h4>Materials and methods</h4>We examined the association between use of common anti-depress ...[more]

PMID: 28944316

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Dataset Information

Relationship between anti-depressant use and lung cancer survival.

Objectives

Materials and methods

Results

Conclusions

Publications

Relationship between anti-depressant use and lung cancer survival.

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