Effects of vitamin D₃ in clinically isolated syndrome and healthy control participants: A double-blind randomised controlled trial.

ABSTRACT:

Background

Lowserum vitamin D levels are associated with susceptibility to, and severity of, multiple sclerosis. High dose vitamin D has been proposed as a potential immunomodulator in multiple sclerosis.

Objectives

We performed a single centre, investigator-led, exploratory, double-blind, randomised, placebo controlled, trial of vitamin D₃ in clinically isolated syndrome and healthy control participants to assess its immunological effects. Secondary end-points included clinical and magnetic resonance imaging outcomes and safety.

Methods

Clinically isolated syndrome patients and healthy control participants were randomised to: placebo, 5000 IU or 10,000 IU vitamin D₃/day (Vigantol oil). Study duration was 24 weeks.

Results

The trial did no

SUBMITTER: O'Connell K 

PROVIDER: S-EPMC5613850 | biostudies-literature | 2017 Jul-Sep

REPOSITORIES: biostudies-literature