Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs.
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ABSTRACT:
SUBMITTER: Syed M
PROVIDER: S-EPMC5660088 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs.
Syed Mansoor M Das Pragnya P Pawar Aishwarya A Aghai Zubair H ZH Kaskinen Anu A Zhuang Zhen W ZW Ambalavanan Namasivayam N Pryhuber Gloria G Andersson Sture S Bhandari Vineet V
Nature communications 20171027 1
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or therapeutic agent is available. Here we show that lung micro-RNA (miR)-34a levels are significantly increased in lungs of neonatal mice exposed to hyperoxia. Deletion or inhibition of miR-34a improves the pulmonary phenotype and BPD-associated pulmonary arterial hypertension (PAH) in BPD mouse models, which, conversely, is worsen ...[more]
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2022-08-18 | MSV000090157 | MassIVE