Dengue virus-reactive CD8⁺ T cells mediate cross-protection against subsequent Zika virus challenge.

ABSTRACT: Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 ^-/- or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8⁺ T cells predominantly mediate cross-protective responses to ZIKV. In contrast, passive transfer studies suggest that DENV-immune serum does not protect against ZIKV infection. Thus, CD8⁺ T cell

SUBMITTER: Wen J 

PROVIDER: S-EPMC5682281 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature