Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract.

ABSTRACT:

Purpose

A better understanding of the molecular basis of urothelial carcinoma (UC) is needed to refine the clinical decision-making process.

Methods and materials

We performed next-generation sequencing to investigate the mutational and transcriptional profiles of commonly mutated genes in UC using Ampliseq v2. Copy number variations (CNVs) were detected with nCounter assay. Genetic alterations between upper tract UC (UTUC) and urinary bladder UC (UBUC) were compared.

Results

Tumor samples from 31 UTUC and 61 UBUC patients were included in analysis. The two groups showed similar clinicopathologic features including tumor grade and stage. Median survival was longer in UTUC than UBUC patients, though this was statistically nonsignificant (59 vs 41 months, P=.137). In to

SUBMITTER: Lee JY 

PROVIDER: S-EPMC5699894 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature