Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

ABSTRACT:

Background

Eosinophils are prominent in some patients with asthma and are increased in the submucosa in a subgroup of obese patients with asthma (OAs). Surfactant protein A (SP-A) modulates host responses to infectious and environmental insults.

Objective

We sought to determine whether SP-A levels are altered in OAs compared with a control group and to determine the implications of these alterations in SP-A levels in asthmatic patients.

Methods

Bronchoalveolar lavage fluid from 23 lean, 12 overweight, and 20 obese subjects were examined for SP-A. Mouse tracheal epithelial cells grown at an air-liquid interface were used for mechanistic studies. SP-A^-/- mice were challenged in allergen models, and exogenous SP-A therapy was given after the last challenge. Eo

SUBMITTER: Lugogo N 

PROVIDER: S-EPMC5732097 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature