Dataset Information

Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland.

ABSTRACT:

Background

Skin cancer incidence in Switzerland is among the highest in the world. In addition to exposure to ultraviolet (UV) radiation, radon alpha particles attached to aerosols can adhere to the skin and potentially cause carcinogenic effects.

Objectives

We investigated the effects of radon and UV exposure on skin cancer mortality.

Methods

Cox proportional hazard regression was used to study the association between exposures and skin cancer mortality in adults from the Swiss National Cohort. Modeled radon exposure and erythemal-weighted UV dose were assigned to addresses at baseline. Effect estimates were adjusted for sex, civil status, mother tongue, education, job position, neighborhood socioeconomic position, and UV exposure from outdoor occupation.

Results

The study included 5.2 million adults (mean age 48 y) and 2,989 skin cancer deaths, with 1,900 indicating malignant melanoma (MM) as the primary cause of death. Adjusted hazard ratios (HR) for MM at age 60 were 1.16 (95% CI: 1.04, 1.29) per 100 Bq/m³ radon and 1.11 (1.01, 1.23) per W/m² in UV dose. Radon effects decreased with age. Risk of MM death associated with residential UV exposure was higher for individuals engaged in outdoor work with UV exposure (HR 1.94 [1.17, 3.23]), though not statistically significantly different compared to not working outdoors (HR 1.09 [0.99, 1.21],

SUBMITTER: Vienneau D

PROVIDER: S-EPMC5744747 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland.

Vienneau Danielle D de Hoogh Kees K Hauri Dimitri D Vicedo-Cabrera Ana M AM Schindler Christian C Huss Anke A Röösli Martin M

Environmental health perspectives 20170616 6

<h4>Background</h4>Skin cancer incidence in Switzerland is among the highest in the world. In addition to exposure to ultraviolet (UV) radiation, radon alpha particles attached to aerosols can adhere to the skin and potentially cause carcinogenic effects.<h4>Objectives</h4>We investigated the effects of radon and UV exposure on skin cancer mortality.<h4>Methods</h4>Cox proportional hazard regression was used to study the association between exposures and skin cancer mortality in adults from the ...[more]

PMID: 28686556

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Project description:Context and objectiveTo date, lung cancer is the only well-established health effect associated with radon exposure in humans. To summarize available evidence on other potential health effects of radon exposure, we performed a comprehensive qualitative and quantitative synthesis of the available literature on radon exposure and health effects other than lung cancer, in both occupational and general populations.MethodEligible studies published from January 1990 to March 2023, in English and French languages, were identified in PubMed, ScienceDirect, Scopus, ScieLo and HAL. In the meta-analysis, we estimated average weighted standardized incidence ratios (metaSIR), standardized mortality ratios (metaSMR), and risk ratio (metaRR) per 100 unit (Bq/m3 or Working level Month) increase in radon exposure concentration by combining estimates from the eligible studies using the random-effect inverse variance method. DerSimonian & Laird estimator was used to estimate the between-study variance. For each health outcome, analyses were performed separately for mine workers, children, and adults in the general population.ResultsA total of 129 studies were included in the systematic review and 40 distinct studies in the meta-analysis. For most of these health outcomes, the results of the meta-analyses showed no statistically significant association, and heterogeneity was only present among occupational studies, especially between those included in the metaSIR or metaSMR analyses. However, the estimated exposure-risk associations were positive and close to the statistical significance threshold for: lymphohematological cancer incidence in children (metaRR = 1.01; 95%CI: 1.00-1.03; p = 0.08); malignant melanoma mortality among adults in the general population (metaRR = 1.10; 95%CI: 0.99-1.21; p = 0.07); liver cancer mortality among mine workers (metaRR = 1.04; 95%CI: 1.00-1.10; p = 0.06); intestine and rectal cancer mortality combined among mine workers (metaRR = 1.02; 95%CI: 1.00-1.04; p = 0.06).ConclusionAlthough none of the exposure-risk associations estimated in the meta-analyses reached statistical significance, the hypothesis that radon may have other health effects apart from lung cancer could not be ruled-out and call for additional research. Larger and well-designed studies are needed to further investigate this question.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023474542, ID: CRD42023474542.

Dataset Information

Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland.

Background

Objectives

Methods

Results

Publications

Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland.

Similar Datasets

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