Ontology highlight
ABSTRACT:
SUBMITTER: Klein BJ
PROVIDER: S-EPMC5758897 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20180101 1
Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-terminal to K27ac stabilizes the complex. The side chain of K27ac inserts between two aromatic residues, mutation of which abrogates the interaction in vitro and leads in vivo to phenotypes similar to ...[more]