Ontology highlight
ABSTRACT: Key messages
•Endometrial receptivity is negatively regulated by LEFTY2. •LEFTY2 inhibits the expression of key murine receptivity genes, including Cox2, Bmp2 and Wnt4, and blocks embryo implantation. •LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. •LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. •Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility.
SUBMITTER: Salker MS
PROVIDER: S-EPMC5778154 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Salker Madhuri S MS Singh Yogesh Y Durairaj Ruban R Peter RRP Yan Jing J Alauddin Md M Zeng Ni N Steel Jennifer H JH Zhang Shaqiu S Nautiyal Jaya J Webster Zoe Z Brucker Sara Y SY Wallwiener Diethelm D Anne Croy B B Brosens Jan J JJ Lang Florian F
Journal of molecular medicine (Berlin, Germany) 20171211 2
Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-β family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the win ...[more]