Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer.

ABSTRACT:

Background

Selenium status is inversely associated with the incidence of prostate cancer. However, supplementation trials have not indicated a benefit of selenium supplementation in reducing cancer risk. Polymorphisms in the gene encoding selenoprotein 15 (SELENOF) are associated with cancer incidence/mortality and present disproportionately in African Americans. Relationships among the genotype of selenoproteins implicated in increased cancer risk, selenium status, and race with prostate cancer were investigated.

Methods

Tissue microarrays were used to assess SELENOF levels and cellular location in prostatic tissue. Sera and DNA from participants of the Chicago-based Adiposity Study Cohort were used to quantify selenium levels and genotype frequencies of the genes for SELEN

SUBMITTER: Ekoue DN 

PROVIDER: S-EPMC5817240 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature