Ontology highlight
ABSTRACT:
SUBMITTER: Park SR
PROVIDER: S-EPMC5835016 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20171005 2
Stem cells introduced to site of injury primarily act via indirect paracrine effects rather than direct cell replacement of damaged cells. This gives rise to understanding the stem cell secretome. In this study, in vitro studies demonstrate that the secretome activates the PI3K/Akt or FAK/ERK1/2 signaling cascades and subsequently enhances the proliferative and migratory abilities of various types of skin cells, such as fibroblasts, keratinocytes, and vascular epithelial cells, ultimately accele ...[more]