Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study.

ABSTRACT: BACKGROUND:Studies suggesting a protective effect of estrogen in neurodegenerative diseases prompted us to investigate this relationship in progressive supranuclear palsy (PSP). METHODS:This case-control study evaluated the self-reported reproductive characteristics and estrogen of 150 women with PSP and 150 age-matched female controls who participated in the Environmental Genetic-PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen. RESULTS:There was no association between years of estrogen exposure duration and PSP. There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance (P = .06). Any exposure to estrogen replacement therapy halved the risk of PSP (odds

SUBMITTER: Park HK 

PROVIDER: S-EPMC5840026 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature