Duox mediates ultraviolet injury-induced nociceptive sensitization in Drosophila larvae.

ABSTRACT:

Background

Nociceptive sensitization is an increase in pain perception in response to stimulus. Following brief irradiation of Drosophila larvae with UV, nociceptive sensitization occurs in class IV multiple dendritic (mdIV) neurons, which are polymodal sensory nociceptors. Diverse signaling pathways have been identified that mediate nociceptive sensitization in mdIV neurons, including TNF, Hedgehog, BMP, and Tachykinin, yet the underlying mechanisms are not completely understood.

Results

Here we report that duox heterozygous mutant larvae, which have normal basal nociception, exhibit an attenuated hypersensitivity response to heat and mechanical force following UV irradiation. Employing the ppk-Gal4 line, which is exclusively expressed in mdIV neurons, we further show that

SUBMITTER: Jang W 

PROVIDER: S-EPMC5852969 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature