Relative Supersaturation of 24-Hour Urine and Likelihood of Kidney Stones.

ABSTRACT:

Purpose

The relative supersaturation of calcium oxalate, calcium phosphate and uric acid is used clinically in kidney stone prevention. The magnitude of the association between relative supersaturation and stone risk requires further quantification.

Materials and methods

We performed a cross-sectional study using 24-hour urine collections from the NHS (Nurses' Health Study) I and II, and HPFS (Health Professionals Follow-up Study) cohorts to quantify the association between the relative supersaturation of calcium oxalate, calcium phosphate and uric acid, and the likelihood of stone formation.

Results

The OR of being a stone former was 5.85 (95% CI 3.40-10.04) in NHS I, 6.38 (95% CI 3.72-11.0) in NHS II and 6.95 (95% CI 3.56-13.6) in HPFS for the highest category of ca

SUBMITTER: Prochaska M 

PROVIDER: S-EPMC5911189 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature