Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4⁺ T Cells.

ABSTRACT: HIV-1 infection of CD4⁺ T cells leads to cytopathic effects and cell demise, which is counter to the observation that certain HIV-1-infected cells possess a remarkable long-term stability and can persist lifelong in infected individuals treated with suppressive antiretroviral therapy (ART). Using quantitative mass spectrometry-based proteomics, we showed that HIV-1 infection activated cellular survival programs that were governed by BIRC5, a molecular inhibitor of cell apoptosis that is frequently overexpressed in malignant cells. BIRC5 and its upstream regulator OX40 were upregulated in productively and latently infected CD4⁺ T cells and were functionally involved in maintaining their viability. Moreover, OX40-expressing CD4⁺ T cells from ART-treated patie

SUBMITTER: Kuo HH 

PROVIDER: S-EPMC6013384 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature