First evaluation of PET-based human biodistribution and radiation dosimetry of ¹¹C-BU99008, a tracer for imaging the imidazoline₂ binding site.

ABSTRACT:

Background

We measured whole body distribution of ¹¹C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline₂ binding site. The purpose of this phase I study was to evaluate the biodistribution and radiation dosimetry of ¹¹C-BU99008 in healthy human subjects.

Methods

A single bolus injection of ¹¹C-BU99008 (296 ± 10.5 MBq) was administered to four healthy subjects who underwent whole-body PET/CT over 120 min from the cranial vertex to the mid-thigh. Volumes of interest were drawn around visually identifiable source organs to generate time-activity curves (TAC). Residence times were determined from time-activity curves. Absorbed doses to individual organs and the whole body effective dose were calculated usi

SUBMITTER: Venkataraman AV 

PROVIDER: S-EPMC6066589 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature