Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus.

ABSTRACT:

Background

Female reproductive tract development is sensitive to the endocrine-disrupting potential of environmental estrogens. Early-life exposure to the dietary phytoestrogen genistein impairs fertility and persistently alters the transcriptome in the oviduct and uterus of rodents. Glucocorticoid signaling, which has recently been shown to be essential for normal fertility in the female mouse uterus, is antagonized by genistein.

Objective

Our goal was to determine whether early-life exposure to genistein disrupts glucocorticoid signaling in the mouse uterus, which may contribute to infertility.

Methods

Female C57Bl/6 mice were exposed to either 50 mg/kg per day genistein, 10 μg/kg per day estradiol, or vehicle (corn oil) on postnatal days 1-5 (PND1-5), and then trea

SUBMITTER: Whirledge SD 

PROVIDER: S-EPMC6071733 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature