Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and the TSLP/TSLPR Axis on Risk of Coronary Artery Disease.

ABSTRACT: The thymic stromal lymphopoietin (TSLP)/TSLP receptor (TSLPR) axis is involved in multiple inflammatory immune diseases, including coronary artery disease (CAD). To explore the causal relationship between this axis and CAD, we performed a three-stage case-control association analysis with 3,628 CAD cases and 3,776 controls using common variants in the genes TSLP, interleukin 7 receptor (IL7R), and TSLPR. Three common variants in the TSLP/TSLPR axis were significantly associated with CAD in a Chinese Han population [rs3806933^T in TSLP, P_adj = 4.35 × 10^-5, odds ratio (OR) = 1.18; rs6897932^T in IL7R, P_adj = 1.13 × 10^-7, OR = 1.31; g.19646A>G^A in TSLPR, P_adj = 2.04 

SUBMITTER: Nie SF 

PROVIDER: S-EPMC6085432 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature