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σ^I from Bacillus subtilis: Impact on Gene Expression and Characterization of σ^I-Dependent Transcription That Requires New Types of Promoters with Extended -35 and -10 Elements.

ABSTRACT: The σ^I sigma factor from Bacillus subtilis is a σ factor associated with RNA polymerase (RNAP) that was previously implicated in adaptation of the cell to elevated temperature. Here, we provide a comprehensive characterization of this transcriptional regulator. By transcriptome sequencing (RNA-seq) of wild-type (wt) and σ^I-null strains at 37°C and 52°C, we identified ∼130 genes affected by the absence of σ^I Further analysis revealed that the majority of these genes were affected indirectly by σ^I The σ^I regulon, i.e., the genes directly regulated by σ^I, consists of 16 genes, of which eight (the dhb and yku operons) are involved in iron metabolism. The involvement of σ^I in iron metabolism was co

SUBMITTER: Ramaniuk O

PROVIDER: S-EPMC6088155 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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σ^I from Bacillus subtilis: Impact on Gene Expression and Characterization of σ^I-Dependent Transcription That Requires New Types of Promoters with Extended -35 and -10 Elements.

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Dataset Information

σI from Bacillus subtilis: Impact on Gene Expression and Characterization of σI-Dependent Transcription That Requires New Types of Promoters with Extended -35 and -10 Elements.

OmicsDI is part of the ELIXIR infrastructure

Tweets

σ^I from Bacillus subtilis: Impact on Gene Expression and Characterization of σ^I-Dependent Transcription That Requires New Types of Promoters with Extended -35 and -10 Elements.