Precision DNA demethylation ameliorates disease in lupus-prone mice.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6141184 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Precision DNA demethylation ameliorates disease in lupus-prone mice.
Li Hao H Tsokos Maria G MG Bickerton Sean S Sharabi Amir A Li Yi Y Moulton Vaishali R VR Kong Philip P Fahmy Tarek M TM Tsokos George C GC
JCI insight 20180823 16
Defective DNA methylation in T cells leads to a series of T cell abnormalities in lupus; however, the full effect of T cell lineage-specific DNA methylation on disease expression has not been explored. Here, we show that 5-azacytidine, a DNA methyltransferase inhibitor, targeted to either CD4 or CD8 T cells in mice with established disease using a nanolipogel delivery system dramatically ameliorates lupus-related pathology through distinct mechanisms. In vivo targeted delivery of 5-azacytidine i ...[more]
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