Human Lymph Nodes Maintain TCF-1^hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life.

ABSTRACT: Translating studies on T cell function and modulation from mouse models to humans requires extrapolating in vivo results on mouse T cell responses in lymphoid organs (spleen and lymph nodes [LN]) to human peripheral blood T cells. However, our understanding of T cell responses in human lymphoid sites and their relation to peripheral blood remains sparse. In this study, we used a unique human tissue resource to study human T cells in different anatomical compartments within individual donors and identify a subset of memory CD8⁺ T cells in LN, which maintain a distinct differentiation and functional profile compared with memory CD8⁺ T cells in blood, spleen, bone marrow, and lungs. Whole-transcriptome and high-dimensional cytometry by time-of-flight profiling reveals th

SUBMITTER: Miron M 

PROVIDER: S-EPMC6143415 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature