Effect of preadmission beta-blockade on mortality in multiple trauma.

ABSTRACT:

Background

High levels of circulating catecholamines after multiple trauma have been associated with increased morbidity and mortality. Beta-adrenergic receptor antagonist (beta-blocker) therapy has emerged as a potential treatment option, but the effect of preinjury beta-blockade on trauma-induced mortality is unclear. The aim of this study was to assess whether preinjury beta-blocker therapy is associated with reduced mortality after multiple trauma.

Methods

Severely injured patients, aged at least 50 years, admitted to a level one trauma centre over a 10-year interval were linked to national and local registries of co-morbidities, prescription drug use and level of education. The association between preinjury beta-blocker use and 30-day mortality was explored using logist

SUBMITTER: Eriksson M 

PROVIDER: S-EPMC6253788 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature