Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV.

ABSTRACT:

Objective

Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk.

Designs/methods

One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evalua

SUBMITTER: Srinivasa S 

PROVIDER: S-EPMC6311412 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature