Dataset Information

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.

ABSTRACT:

Introduction

Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear.

Objective

To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study.

Methods

We conducted a cross-sectional study of 317 women enrolled in the EARTH Study, a prospective preconception cohort that recruits Boston area couples. Using samples collected at study entry, we quantified urinary triclosan and serum thyroid function biomarker concentrations, specifically free and total thyroxine and triiodothyronine, thyroid-stimulating hormone (TSH), and thyroid antibodies. We estimated covariate-adjusted differences in thyroid function biomarkers per 10-fold increase in triclosan using linear regression models. We examined effect modification by body mass index (BMI) and infertility diagnosis.

Results

The median urinary triclosan concentration was 7.8 μg/L (IQR: 3.0-59 μg/L). Each 10-fold increase in triclosan was inversely associated with free triidothyronine (T₃) (β: -0.06 pg/mL; 95% CI: -0.1, -0.01), thyroperoxidase antibody (TPOAb) (-10%; 95% CI: -19, -0.4), and thyroglobulin antibody (TgAb) (-12%; 95% CI: -23,0.9) concentrations. BMI and infertility diagnosis modified the association of triclosan with free T₃ and TPOAb, respectively.

Conclusion

Urinary triclosan concentrations were inversely associated with specific serum thyroid function biomarkers in this cohort, suggesting that triclosan may affect thyroid homeostasis and autoimmunity.

SUBMITTER: Skarha J

PROVIDER: S-EPMC6317095 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.

Skarha Julianne J Mínguez-Alarcón Lidia L Williams Paige L PL Korevaar Tim I M TIM de Poortere Ralph A RA Broeren Maarten A C MAC Ford Jennifer B JB Eliot Melissa M Hauser Russ R Braun Joseph M JM

Environment international 20181123

<h4>Introduction</h4>Exposure to the antimicrobial agent triclosan is ubiquitous. Research in animals shows that triclosan can cause decreases in thyroxine concentrations. However, the potential effects of triclosan on thyroid function in humans are unclear.<h4>Objective</h4>To estimate the association between urinary triclosan concentrations and serum thyroid function biomarkers in women seeking assisted reproduction treatment in the Environment and Reproductive Health (EARTH) Study.<h4>Methods ...[more]

PMID: 30477815

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Dataset Information

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.

Introduction

Objective

Methods

Results

Conclusion

Publications

Cross-sectional associations between urinary triclosan and serum thyroid function biomarker concentrations in women.

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