Constructing network topologies for multiple signal-encoding functions.

ABSTRACT:

Background

Cells use signaling protein networks to sense their environment and mediate specific responses. Information about environmental stress is usually encoded in the dynamics of the signaling molecules, and qualitatively distinct dynamics of the same signaling molecule can lead to dramatically different cell fates. Exploring the design principles of networks with multiple signal-encoding functions is important for understanding how distinct dynamic patterns are shaped and integrated by real cellular networks, and for building cells with targeted sensing-response functions via synthetic biology.

Results

In this paper, we investigate multi-node enzymatic regulatory networks with three signal-encoding functions, i.e., dynamic responses of oscillation, transient activation

SUBMITTER: Wu L 

PROVIDER: S-EPMC6330498 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature