Ontology highlight
ABSTRACT:
SUBMITTER: Oshima T
PROVIDER: S-EPMC6357737 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Science advances 20190123 1
Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we identified GO289, which strongly lengthened circadian period, as a potent and selective inhibitor of CK2. Phosphoproteomics identified multiple phosphorylation sites inhibited by GO289 on clock proteins, including PER2 S693. Furthermor ...[more]