Atoh1⁺ secretory progenitors possess renewal capacity independent of Lgr5⁺ cells during colonic regeneration.

ABSTRACT: During homeostasis, the colonic epithelium is replenished every 3-5 days by rapidly cycling Lgr5 ⁺ stem cells. However, various insults can lead to depletion of Lgr5 ⁺ stem cells, and colonic epithelium can be regenerated from Lgr5-negative cells. While studies in the small intestine have addressed the lineage identity of the Lgr5-negative regenerative cell population, in the colon this question has remained unanswered. Here, we set out to identify which cell(s) contribute to colonic regeneration by performing genetic fate-mapping studies of progenitor populations in mice. First, using keratin-19 (Krt19) to mark a heterogeneous population of cells, we found that Lgr5-negative cells can regenerate colonic crypts and give

SUBMITTER: Castillo-Azofeifa D 

PROVIDER: S-EPMC6376326 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature