Regulation of erythrocyte Na⁺/K⁺/2Cl^- cotransport by an oxygen-switched kinase cascade.

ABSTRACT: Many erythrocyte processes and pathways, including glycolysis, the pentose phosphate pathway (PPP), KCl cotransport, ATP release, Na⁺/K⁺-ATPase activity, ankyrin-band 3 interactions, and nitric oxide (NO) release, are regulated by changes in O₂ pressure that occur as a red blood cell (RBC) transits between the lungs and tissues. The O₂ dependence of glycolysis, PPP, and ankyrin-band 3 interactions (affecting RBC rheology) are controlled by O₂-dependent competition between deoxyhemoglobin (deoxyHb), but not oxyhemoglobin (oxyHb), and other proteins for band 3. We undertook the present study to determine whether the O₂ dependence of Na⁺/K⁺/2Cl^- cotransport (catalyzed by Na⁺/K^+</

SUBMITTER: Zheng S 

PROVIDER: S-EPMC6378966 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature